The prognostic value of sentinel lymph node micrometastases in patients with invasive breast carcinoma

Abstract

AIM: The prognostic value of sentinel lymph node micrometastases in invasive breast cancer patients is still Even if, in the absence of unequivocal guidelines, the axillary lynphadenectomy is not still performed in the clinical care of these patients. METHOD: We have retrospectively analyzed 746 patients with operable invasive breast cancer and clinically negative axillary lymph nodes. These patients underwent conservative surgery or total mastectomy with sentinel lymph Patients with micrometastases in the sentinel lymph node treated with axillary dissection has been checked and the involvement of the remaining lymph nodes analyzed. Patients with micrometastases in the SLN not followed by axillary dissection have been checked as well and the incidence of recurrences has been evaluated in both groups. RESULTS: Micrometastases were found in 51 (6.83%) patients and isolated tumor cells in 8 (1.07%) patients section and confirmed at the final hystopathologic examination. Fifteen of these patients underwent complete axillary dissection two of them (13.33%) had metastatic involvement of other axillary lymph nodes. The other 44 patients receive further surgical axillary procedure. No axillary recurrences in these patients were found during a up of 65-3±9.65 months (range 42-78 months). CONCLUSION: Based on the results and according to some recent randomized trials we can say that axillary lynphadenectomy can be avoided when micrometastases are found in sentinel lynph nodes. It should be performed anyway, the analysis of the biomedical profile of the tumor.