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ANTONIO CASCIO

Comparative study of a whole-cell pertussis vaccine and a recombinant acellular pertussis vaccine

  • Authors: PODDA A; DELUCA EC; CONTU B; FURLAN R; MAIDA A; MOIRAGHI A; STRAMARE D; TITONE L; UXA F; DIPISA F; PEPPOLONI S; NENCIONI L; RAPPUOLI R; BARTALINI M; BONA G; BUDRONI M; PISTILLI AMC; CASCIO A; CASCIO G; COSSU M; DALLORTO P; DILEO G; FURLAN A; MACAGNO F; MARSILI I; MELONI T; REGOLI D; RIGO G; TRAPPAN A; VARGIU G; VOLPINI G
  • Publication year: 1994
  • Type: Articolo in rivista
  • Key words: BORDETELLA-PERTUSSIS
  • OA Link: http://hdl.handle.net/10447/415736

Abstract

The safety and immunogenicity of an acellular pertussis vaccine containing the genetically detoxified pertussis toxin PT-9K/129G, filamentous hemagglutinin, and pertactin, together with diphtheria and tetanus toxoids, were compared with those of a whole-cell pertussis component-diphtheria-tetanus vaccine. Four hundred eighty infants were enrolled into this prospective, multicenter, double-blind study. Each infant was randomly given three doses of one of the two vaccines at 2, 4, and 6 months of age. Both local and systemic adverse reactions, reported within 48 hours and 7 days of each injection, were less frequent after the acellular vaccine than after the whole-cell vaccine. The enzyme-linked immunosorbent assay titers to pertussis toxin, filamentous hemagglutinin, and pertactin, as well as the pertussis toxin-neutralizing titer measured by the Chinese hamster ovary cell assay, were significantly higher after the acellular vaccine was given. Both vaccines induced adequate levels of anti-diphtheria and anti-tetanus antibodies. We conclude that the recombinant acellular pertussis vaccine produces fewer reactions than the whole-cell vaccine and provides a high antibody response against the antigens of Bordetella pertussis involved in bacterial adhesion and systemic toxic effects.