Elevating fungal care: bridging Brazil’s healthcare practices to global standards
- Autori: Salmanton-García, Jon; Falci, Diego R.; Cornely, Oliver A.; Pasqualotto, Alessandro C.; null, null; Barth, Afonso L.; Denning, David W.; Riera, Fernando; Cimerman, Sergio; Colombo, Arnaldo L.; Aquino, Valerio R.; Vena, Antonio; Özenci, Volkan; Lagrou, Katrien; Arikan-Akdagli, Sevtap; Izquierdo, Ana Alastruey; Segal, Esther; Gangneux, Jean-Pierre; Hoenigl, Martin; Mano, Vasilika; Zakharyan, Anahit; Soghomonyan, Diana; Salzer, Helmut J.F.; Willinger, Birgit; Hseyn, Ravil; Mammadova, Naila; Sidarenka, Anastasiya; Kandaurava, Sviatlana; Boel, An; Vanheule, Geert; Reynders, Marijke; Clevenbergh, Philippe; Packeu, Ann; Degeyter, Deborah; Overmeire, Yarah; Boelens, Jerina; Ide, Louis; Cartuyvels, Reinoud; Moreau, Anne-Isabelle de; Layios, Nathalie; Goegebuer, Truus; Verbeeck, Peter; Travar, Maja; Ljubović, Amela Dedeić; Malkodanski, Ivan; Dimova, Diana; Velikova, Tsvetelina; Philipova, Ivva; Cviljevic, Sabina; Kučinar, Jasmina; Abram, Maja; Matas, Ivanka; Janes, Andrea; Klarić, Maja Šegvić; Bukovski, Suzana; Smirnjak, Ljiljana Cicmak; Čičmak, Ana; Karagiannis, Christos; Lengerová, Martina; Hamal, Petr; Dobiáš, Radim; Chrenkova, Vanda; Lyskova, Pavlina; Ráčil, Zdeněk; Søndergaard, Turid Snekloth; Kristensen, Lise; Smith, Birgitte; Arendrup, Maiken Cavling; Rosenvinge, Flemming Schønning; Christensen, Jens Jørgen; Kirs, Kaisa; Pirozkova, Linda; Järv, Helle; Jürna-Ellam, Marika; Lõivukene, Krista; Friberg, Nathalie; Kauranen, Jari; Billon, Laura; Govic, Yohann Le; Bouchara, Jean-Philippe; Blanc, Véronique; Plantefeve, Gaetan; Millon, Laurence; Laurent, G; Brun, Sophie; Gabriel, Frédéric; Gal, Solène Le; Bonhomme, Julie; Poirier, Philippe; Fouquet, Guillemette; Botterel, Françoise; Dalle, Frederic; Garnaud, Cécile; Pelerin, Helene; Sendid, Boualem; Durieux, Marie-Fleur; Menotti, Jean; Ranque, Stéphane; Labbé, Franck; Lachaud, Laurence; Morio, Florent; Hasseine, Lilia; Sasso, Milène; Courtellemont, Laura; Alanio, Alexandre; Bougnoux, Marie-Elisabeth; Hennequin, Christophe; Cadranel, Jacques; Fekkar, Arnaud; Dannaoui, Eric; Bonnal, Christine; Perraud-Cateau, Estelle; Huguenin, Antoine; Costa, Damien; Sabou, Marcela; Janvier, Frederic; Cassaing, Sophie; Desoubeaux, Guillaume; Mazars, Edith; Didbaridze, Tamar; Malania, Lile; Bohnert, Jürgen; Haase, Gerhard; Buchberger, Tatjana; Schwartz, Stefan; Sassmann-Schweda, Antonia; Müller, Lutz von; Held, Jürgen; Lehrnbecher, Thomas; Kiehl, Michael; Trauth, Janina; Dudakova, Anna; Schröder, Maria; Sedlacek, Ludwig; Klein, Sabrina; Becker, Soeren; Fickenscher, Helmut; Schildgen, Oliver; Prados, Benigno Florido; Gräber, Sandra; Eberwein, Lukas; Hauswaldt, Susanne; Schalk, Enrico; Groll, Andreas; Karthaus, Meinolf; Lahmer, Tobias; Dichtl, Karl; Steinmann, Joerg; Berger, Anja; Hamprecht, Axel; Vöhringer, Matthias; Simon, Michaela; Lobermann, Micha; Schmid, Michael; Paul, Gregor; Schmidt, Annika; Furitsch, Martina; Ghebremedhin, Beniam; Kurzai, Oliver; Panopoulou, Maria; Vrioni, Georgia; Meletiadis, Joseph; Stathi, Angeliki; Maraki, Sofia; Gartzonika, Konstantina; Gkentzi, Despoina; Roilides, Emmanuel; Mandros, Charalampos; Vad, Eszter; Majoros, László; Sonnevend, Agnes; Dóczi, Ilona; Hilmarsdottir, Ingibjorg; Sibartie, Shomik; O'Sullivan, Niamh; McConkey, Sam; Talento, Alida Fe; Dinesh, Binu; O'Connell, Brian; Lynch, Breda; Stapleton, Patrick; Oren, Ilana; Chetrit, Eli Ben; Korem, Maya; En-Dror, Shifra; A'laa, Alkrenawi; Ben-Ami, Ronen; Monno, Rosa; Buquicchio, Caterina; Farina, Claudio; Bartoletti, Michele; Cattaneo, Chiara; Angioni, Goffredo; Papa, Mario Virgilio; Mikulska, Malgorzata; Castagnola, Elio; Danesi, Patrizia; Cuccaro, Annarosa; Romeo, Orazio; Oltolini, Chiara; Grancini, Anna; Antinori, Spinello; Lombardi, Gianluigi; Forghieri, Fabio; Maraolo, Alberto Enrico; Coppola, Nicola; Itri, Federico; Cortegiani, Andrea; Prezioso, Lucia; Perruccio, Katia; Barchiesi, Francesco; Cascio, Giuliana Lo; Raponi, Giammarco; Marchesi, Francesco; Principe, Maria
- Anno di pubblicazione: 2025
- Tipologia: Articolo in rivista
- OA Link: http://hdl.handle.net/10447/675008
Abstract
Brazil faces unique challenges in managing invasive fungal infections (IFIs) due to diverse ecosystems, a rural workforce, and prevalent health conditions. In Europe, IFIs are primarily associated with transplantation, intensive care, and chronic diseases. Inspired by initiatives in the Caribbean and Latin America in 2019, efforts to map global diagnostic and treatment resources expanded to Africa, Europe, and Asia/Pacific. This study conducts a comparative analysis, mainly drawing data from Brazil and Europe, to investigate IFI epidemiology and management. Data were collected through online surveys distributed to Brazilian and European institutions, with collaborations from scientific organizations. Surveys covered institutional profiles, IFI diagnoses, accessibil ity to diagnostic techniques, and antifungal drugs. A comparative survey involving 96 Brazilian and 388 European institutions revealed variations in the perception and practices related to fungal pathogens. Differences in ranking and prevalence were observed, along with variations in diagnostic procedures, fluorescence dye usage, culture practices, antifungal medication availability, and technological approaches. Europe exhibited higher utilization rates for molecular diagnostic approaches, including PCR tests, and therapeutic drug monitoring (TDM) was more widespread in Europe compared with Brazil, indicating substantial differences in understanding and managing fungal infections. Customized IFI management is crucial, considering regional differences and addressing technological gaps like underutilized PCR. The study advocates for increased international collaboration, targeted training, and enhanced resources to foster a unified global approach in preventing, diagnosing, and treating IFI.