Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms
- Autori: Citarella, Barbara Wanjiru; Kartsonaki, Christiana; Ibáñez-Prada, Elsa D.; Gonçalves, Bronner P.; Baruch, Joaquin; Escher, Martina; Pritchard, Mark G.; Wei, Jia; Philippy, Fred; Dagens, Andrew; Hall, Matthew; Lee, James; Kutsogiannis, Demetrios James; Wils, Evert-Jan; Fernandes, MarÃlia Andreia; Tirupakuzhi Vijayaraghavan, Bharath Kumar; Panda, Prasan Kumar; Martin-Loeches, Ignacio; Ohshimo, Shinichiro; Fatoni, Arie Zainul; Horby, Peter; Dunning, Jake; Rello, Jordi; Merson, Laura; Rojek, Amanda; Vaillant, Michel; Olliaro, Piero; Reyes, Luis Felipe; Moharam, S.A.; Abdalasalam, Sabriya; Abdalhadi, Alaa Abdalfattah; Abdalla, Naana Reyam; Abdalla, Walaa; Abdalrheem, Almthani Hamza; Abdalsalam, Ashraf; Abdeewi, Saedah; Abdelgaum, Esraa Hassan; Abdelhalim, Mohamed; Abdelkabir, Mohammed; Abdelrahman, Israa; Abdukahil, Sheryl Ann; Abdulbaqi, Lamees Adil; Abdulhamid, Salaheddin; Abdulhamid, Widyan; Abdulkadir, Nurul Najmee; Abdulwahed, Eman; Abdunabi, Rawad; Abe, Ryuzo; Abel, Laurent; Abodina, Ahmed Mohammed; Abrous, Amal; Absil, Lara; Jabal, Kamal Abu; Salah, Nashat Abu; Abusalama, Abdurraouf; Abuzaid, Tareg Abdallah; Acharya, Subhash; Acker, Andrew; Adam, Elisabeth; Adem, Safia; Ademnou, Manuella; Adewhajah, Francisca; Adrião, Diana; Afum-Adjei Awuah, Anthony; Agbogbatey, Melvin; Al Ageel, Saleh; Ahmed, Aya Mustafa; Ahmed, Musaab Mohammed; Ahmed, Shakeel; Alaraji, Zainab Ahmed; Elhefnawy Enan, Abdulrahman Ahmed; Ahmed Khalil, Reham Abdelhamid; Ahmed Mohamed Abdelaziz, Ali Mostafa; Ainscough, Kate; Airlangga, Eka; Aisa, Tharwat; Aisha, Ali; Aisha, Bugila; Hssain, Ali Ait; Tamlihat, Younes Ait; Akimoto, Takako; Akmal, Ernita; Akwani, Chika; Al Qasim, Eman; Alajeeli, Ahmed; Alali, Ahmed; Alalqam, Razi; Alameen, Aliya Mohammed; Al-Aquily, Mohammed; Alaraji, Zinah A.; Albakry, Khalid; Albatni, Safa; Alberti, Angela; Aldabbourosama, Osama; Al-dabbous, Tala; Aldhalia, Amer; Aldoukali, Abdulkarim; Alegesan, Senthilkumar; Alessi, Marta; Alex, Beatrice; Alexandre, Kévin; Al-Fares, Abdulrahman; Alflite, Asil; Alfoudri, Huda; Alhadad, Qamrah; Alhaddad, Hoda Salem; Mohamed Abdalla Alhasan, Maali Khalid; Alhouri, Ahmad Nabil; Alhouri, Hasan; Ali, Adam; Ali, Imran; TagElser Mohammed Ali, Maha; Abbas, Syed Ali; Abdelghafar, Yomna Ali; Sheikh, Naseem Ali; Alidjnou, Kazali Enagnon; Aljadi, Mahmoud; Aljamal, Sarah; Alkahlout, Mohammed; Alkaseek, Akram; Alkhafajee, Qabas; Allavena, Clotilde; Allou, Nathalie; Almasri, Lana; Almjersah, Abdulrahman; Alqandouz, Raja Ahmed; Alrfaea, Walaa; Alrifaee, Moayad; Alsaadi, Rawan; Al-Saba'a, Yousef; Alshareea, Entisar; Alshenawy, Eslam; Altaf, Aneela; Alves, João Melo; Alves, João; Alves, Rita; Cabrita, Joana Alves; Amaral, Maria; Amer, Amro Essam; Amira, Nur; Adusei, Amos Amoako; Amuasi, John; Andini, Roberto; Andrejak, Claire; Angheben, Andrea; Angoulvant, François; Ankrah, Sophia; Ansart, Séverine; Anthonidass, Sivanesen; Antonelli, Massimo; Antunes de Brito, Carlos Alexandre; Apriyana, Ardiyan; Arabi, Yaseen; Aragao, Irene; Arancibia, Francisco; Araujo, Carolline; Arcadipane, Antonio; Archambault, Patrick; Arenz, Lukas; Arlet, Jean-Benoît; Arnold-Day, Christel; Arora, Lovkesh; Arora, Rakesh; Artaud-Macari, Elise; Aryal, Diptesh; Asensio, Angel; Ashley, Elizabeth A.; Ashraf, Muhammad; Ashraf, Muhammad Sheharyar; Ben Ashur, Abir; Asiedu-Bekoe, Franklin; Asif, Namra; Asim, Mohammad; Assi, Grace; Assie, Jean Baptiste; Asyraf, Amirul; Atangana, Fouda; Atia, Ahmed; Atif, Minahel; Abdelrhman Abdallahrs, Asia Atif; Atique, Anika; Atlowly, Moad; Attanyake, AM Udara Lakshan; Auchabie, Johann; Aumaitre, Hugues; Auvet, Adrien; Ali Mohammed, Abdelmalek Awad; Axelsen, Eyvind W.; Ayad, Ared; Hassan Helmi, Ahmed Ayman; Azemar, Laurène; Azizeldin, Mohammed; Azoulay, Cecile; Babatunde, Hakeem; Bach, Benjamin; Bachelet, Delphine; Badr, Claudine; Bævre-Jensen, Roar; Baig, Nadia; Baillie, John Kenneth; Baird, J Kevin; Bak, Erica; Bakakos, Agamemnon; Bakar, Nazreen Abu; Bakeer, Hibah
- Anno di pubblicazione: 2024
- Tipologia: Articolo in rivista
- OA Link: http://hdl.handle.net/10447/637479
Abstract
Background: COVID-19 is primarily known as a respiratory illness; however, many patients present to hospital without respiratory symptoms. The association between non-respiratory presentations of COVID-19 and outcomes remains unclear. We investigated risk factors and clinical outcomes in patients with no respiratory symptoms (NRS) and respiratory symptoms (RS) at hospital admission. Methods: This study describes clinical features, physiological parameters, and outcomes of hospitalised COVID-19 patients, stratified by the presence or absence of respiratory symptoms at hospital admission. RS patients had one or more of: cough, shortness of breath, sore throat, runny nose or wheezing; while NRS patients did not. Results: Of 178,640 patients in the study, 86.4 % presented with RS, while 13.6 % had NRS. NRS patients were older (median age: NRS: 74 vs RS: 65) and less likely to be admitted to the ICU (NRS: 36.7 % vs RS: 37.5 %). NRS patients had a higher crude in-hospital case-fatality ratio (NRS 41.1 % vs. RS 32.0 %), but a lower risk of death after adjusting for confounders (HR 0.88 [0.83-0.93]). Conclusion: Approximately one in seven COVID-19 patients presented at hospital admission without respiratory symptoms. These patients were older, had lower ICU admission rates, and had a lower risk of in-hospital mortality after adjusting for confounders.