Characterization of PLLA scaffolds for biomedical applications
- Authors: Fiorentino, S.; Carfì Pavia, F.; La Carrubba, V.; Brucato, V.; Abrami, M.; Farra, R.; Turco, G.; Grassi, G.; Grassi, M.
- Publication year: 2017
- Type: Articolo in rivista (Articolo in rivista)
- OA Link: http://hdl.handle.net/10447/260295
Abstract
The porosity and pore size distribution of three-dimensional scaffolds have direct implications on their biomedical applications (tissue engineering, drug delivery, and wound dressing). Accordingly, in this paper, a fast, facile, and conservative method relying on low-field nuclear magnetic resonance (LF-NMR) for the evaluation of mean pore size and pore size distribution of polymeric scaffolds is reported. The applicability of the technique is demonstrated on poly-L-lactic acid scaffolds fabricated using the thermal induced phase separation. Results obtained through LF-NMR are successfully compared to scanning electron microscope and X-ray microcomputed tomography micrographs