Synthesis of the new ring system pyrrolizino[2,3-b]indol-4(5H)-one
- Autori: Diana, P; Stagno, A; Barraja, P; Montalbano, A; Carbone, A; Parrino, B; Cirrincione G
- Anno di pubblicazione: 2011
- Tipologia: Articolo in rivista (Articolo in rivista)
- Parole Chiave: Pyrrolizino[2,3-b]indol-4(5H)-one Tripentone Antitumor activity Antitubulin agents
- OA Link: http://hdl.handle.net/10447/55073
Abstract
Derivatives of the new ring system pyrrolizino[2,3-b]indol-4(5H)-one were prepared in four steps starting from substituted benzonitriles bearing a functionalized amino group in the adjacent position. The unsubstituted- and the dimethoxy-pyrrolizinoindolones 5a and 5b exhibited modest activity against the HL-60(TB) human leukemia cell line, whereas the N-methylated dimethoxy-pyrrolizinoindolone 6b showed to be selective against MOLT-4 leukemia, A549/ATCC, HOP-92, and NCI-H460 non-small cell lung cancer, and CAKI-1 renal cancer cell lines.