Pyrido[2’,3’:4,5]pyrrolo[2,1-d][1,2,3,5]tetrazine-4(3H)-ones, a new class of temozolomide heteroanalogues
- Autori: DIANA, P; STAGNO, A; BARRAJA, P; MONTALBANO, A; MARTORANA, A; CARBONE, A; DATTOLO, G; CIRRINCIONE, G
- Anno di pubblicazione: 2009
- Tipologia: Articolo in rivista (Articolo in rivista)
- Parole Chiave: Temozolomide Mitozolomide, pyrrolo[2,1-d][1,2,3,5]tetrazinones; Antitumor activity, pyrido[2’,3’:4,5]pyrrolo[2,1-d][1,2,3,5]tetrazines
- OA Link: http://hdl.handle.net/10447/45618
Abstract
Twelve derivatives of new ring system pyrido[2’,3’:4,5]pyrrolo[2,1-d][1,2,3,5]tetrazine were prepared in good yields by reaction of 2-diazo-3-ethoxycarbonyl-pyrrolo[3,2-b]pyridine with alkyl- or aryl-isocyanates. Nine derivatives, screened by the National Cancer Institute (Bethesda, MD) for the in vitro one dose primary anticancer assay against a panel of about 60 human tumor cell lines, showed no significant activity.