Lipase-catalysed preparation of acyl derivatives of the germacranolide sesquiterpenoid cnicin
- Autori: Monsalve, LN; Rosselli, S; Bruno, M; Baldessari, A
- Anno di pubblicazione: 2009
- Tipologia: Articolo in rivista (Articolo in rivista)
- Parole Chiave: enzyme catalysis, acylation, alcoholysis, sesquiterpenoids, cnicin
- OA Link: http://hdl.handle.net/10447/45696
Abstract
Several acyl derivatives of cnicin were obtained through lipase-catalysed acylation and alcoholysis reactions. In most reactions lipases showed a regioselective behaviour affording only one product. Longer chain acyl derivatives were prepared at lower temperature than the used in lipase-catalysed reactions, to preclude side products formation. The enzymatic approach let to prepare a family of novel acetyl and fatty acid derivatives of cnicin which are not obtainable following traditional organic synthetic procedures.