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GIUSEPPE BADALAMENTI

Natural history of bone metastasis in colorectal cancer: final results of a large Italian bone metastases study

  • Authors: Santini d; Tampellini m; Vincenzi b; Ibrahim t; Ortega c; Virzi v; Silvestris n; Berardi r; Masini c; Calipari n; Ottaviani d; Catalano v; Badalamenti g; Giannicola r; Fabbri f; Venditti o; Fratto e; Mazzara c; Latiano tp; Bertolini f; Petrelli f; Ottone a; Caroti c; Salvatore l; Falcone a; Giordani p; Addeo r; Aglietta m; Cascinu s; Barni s.; Maiello e; Tonini g
  • Publication year: 2012
  • Type: Articolo in rivista (Articolo in rivista)
  • OA Link: http://hdl.handle.net/10447/75251

Abstract

Background: Data are limited regarding bone metastases from colorectal cancer (CRC). The objective of this study was to survey the natural history of bone metastasis in CRC. Patients and methods: This retrospective, multicenter, observational study of 264 patients with CRC involving bone examined cancer treatments, bone metastases characteristics, skeletal-related event (SRE) type and frequency, zoledronic acid therapy, and disease outcomes. Results: Most patients with bone metastases had pathologic T3/4 disease at CRC diagnosis. The spine was the most common site involved (65%), followed by hip/pelvis (34%), long bones (26%), and other sites (17%). Median time from CRC diagnosis to bone metastases was 11.00 months; median time to first SRE thereafter was 2.00 months. Radiation and pathologic fractures affected 45% and 10% of patients, respectively; 32% of patients had no reported SREs. Patients survived for a median of 7.00 months after bone metastases diagnosis; SREs did not significantly affect survival. Subgroup analyses revealed that zoledronic acid significantly prolonged median time to first SRE (2.00 months versus 1.00 month, respectively, P = 0.009) and produced a trend toward improved overall survival versus no zoledronic acid. Conclusion: This study illustrates the burden of bone metastases from CRC and supports the use of zoledronic acid in this setting.