Effects of Zoledronic Acid on Cathepsin K circulating levels in patients with bone metastasis.
- Authors: TUMMINELLO FM; BADALAMENTI G; INCORVAIA L; FULFARO F; CRESCIMANNO M; FLANDINA C; GEBBIA N; LETO C
- Publication year: 2007
- Type: Proceedings
- Key words: zoledronic acid, cathepsin k, bone metastases
- OA Link: http://hdl.handle.net/10447/13126
Abstract
Cathepsin K serum levels were determinated in patients with bone metastases from breast cancer or prostate cancer in therapy with zoledronic acid or in patients or in patients with located breast or prostate cancer end in patients with non malignant diseases and in healthy blood. donors (control group). Cathepsin K serum levels were significantly more eleved in healthy subjects or in patients with peimary osteoporosis. Furthermore, the administration of Zoledronic acid to patients with metastatic bome disease from breast or prostate cancer, induced a marked increase of Cathepsin K serum levels.