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GIULIA BIVONA

Study of hypothalamic metabolism in cluster headache by proton MR spectroscopy

  • Authors: LODI R; PIERANGELI G; TONON C; CEVOLI S; TESTA C; BIVONA G; MAGNIFICO F; CORTELLI P; MONTAGNA P; BARBIROLI B
  • Publication year: 2006
  • Type: Articolo in rivista (Articolo in rivista)
  • OA Link: http://hdl.handle.net/10447/14018

Abstract

The authors used 1H-MRS to investigate hypothalamic metabolism in 26 patients with cluster headache (CH) and 12 healthy subjects. Hypothalamic N-acetylaspartate/creatine was reduced in patients with CH vs controls (p < 0.01). Dividing the patients into episodic CH outside- and in-cluster periods and chronic CH, the hypothalamic N-acetylaspartate/creatine in all three subgroups of patients was reduced. The reduction of the neuronal marker N-acetylaspartate is consistent with hypothalamic neuronal dysfunction in patients with CH.