Analysis of the haemodynamic changes caused by surgical and transcatheter aortic valve replacements by means fluid-structure interaction simulations

Abstract

Aortic valve replacements, both surgical and transcatheter, are nowadays widely employed treatments. Although clinically effective, these procedures are correlated with potentially severe clinical complications which can be associated with the non-physiological haemodynamics that they establish. In this work, the fluid dynamics changes produced by surgical and transcatheter aortic valve replacements are analysed and compared with an ideal healthy native valve configuration, employing advanced fluid-structure interaction (FSI) simulations. The aim of the study is to investigate how existing treatments may affect the aortic valve function, and giving indications about how to improve current therapies. Simulations were performed using the commercial software LS-DYNA, where the FSI strategy is based on the coupling of a Lagrangian approach for the structures and a Eulerian approach for the fluid, whilst the coupling between the two domains is reached through a hybrid arbitrary-Lagrangian-Eulerian algorithm. Idealised geometries are used for the aortic root and leaflets. The aortic wall was modelled as linear elastic material, whilst leaflets were modelled as hyperelastic incompressible, using an Ogden's constitutive model. A combination of physiological flow velocity and pressure differences are applied as boundary conditions to model realistically the whole cardiac cycle. Results are analysed throughout the cardiac cycle in terms of leaflets kinematics, flow dynamics, pressure and valve performance parameters. Globally, surgical valves presented worse performance than transcatheter counterparts (reduced effective orifice area, increased transvalvular pressure drop and increased opening and closing times). The clinical parameters of transcatheter devices were improved and closer to those of the healthy native valve, although the vortical activity within the Valsalva's sinuses was substantially altered. Here, the presence of the partition obstructed the washing out, resulting in higher degree of blood stasis and potential blood damage. The implantation of prosthetic devices produces major haemodynamic changes which alters the valve dynamics and leads to diminished performance. Currently, the design of these substitutes is not optimised to mimic realistic native conditions, particularly in terms of valve opening behaviour. Although transcatheter devices provide systolic performance similar to that estimated for the healthy native aortic model, none of the prosthetic solutions appeared to be able to fully restore healthy physiological conditions.