Analysis of Brain–Body Physiological Rhythm Using Functional Graphical Models

Abstract

This paper presents an analysis of physiological data derived from a re- cent investigation on network physiology, adopting the conceptual framework that views the human organism as a complex network of interacting organs. The study explores coordinated interactions among organs using functional conditional Gaussian Graphical Models (fcGGM). Organ functions are modelled as networks with individual regulatory mechanisms, forming a broader system through continuous interactions. The focus of the analysis is on the interactions within and between two subnetworks: brain activity and a composite network comprising the RR interval of the electrocardiographic waveform, respiration amplitude and blood volume pulse.