miR-155 regulative network in FLT3 mutated acute myeloid leukemia
- Authors: Salemi, D; Cammarata, G; Agueli, C; Augugliaro, L; Corrado, C; Bica. MG; Raimondo, S; Marfia, A; Randazzo, V; Dragotto, P; Di Raimondo, F; Alessandro, R; Fabbiano, F; Santoro, A
- Publication year: 2015
- Type: Articolo in rivista (Articolo in rivista)
- OA Link: http://hdl.handle.net/10447/145096
Abstract
Acute myeloid leukemia (AML) represents a heterogeneous disorder with recurrent chromosomal alterations and molecular abnormalities. Among AML with normal karyotype (NK-AML) FLT3 activating mutation, internal tandem duplication (FLT3-ITD), is present in about 30% of patients, conferring unfavorable outcome. Our previous data demonstrated specific up-regulation of miR-155 in FLT3-ITD+ AML. miR-155 is known to be directly implicated in normal hematopoiesis and in some pathologies such as myeloid hyperplasia and acute lymphoblastic leukemia.