Opportunità di lavoro
SCADENZA < APRILE 2017
Due Posizioni post-doc presso Biophysical Chemistry of Macromolecules
(LCBM) di Lausanne, Switzerland
contact information: Prof. Beat Fierz -
École Polytechnique Fédérale de Lausanne SB ISIC LCBM CH B3 485 Station 6
CH-1015 Lausanne
Switzerland
tél: +41 21 69 37153
Our laboratory of Biophysical Chemistry of Macromolecules (LCBM)
at the EPFL in Lausanne, Switzerland offers two fully funded position on the postdoctoral level
in the field of in Biophysical Chemistry of Chromatin for the ERC funded project
“Chromo-SUMMIT: Decoding dynamic chromatin signaling by single-molecule multiplex detection”
Transient multivalent interactions are critical for biological processes such as signaling pathways controlling chromatin function.
Chromatin, the nucleoprotein complex organizing the genome, is dynamically regulated by post-translational modifications (PTMs)
of the chromatin fiber. Protein effectors interact with combinations of these PTMs through multivalent interactions, deposit novel PTMs,
thereby propagate signaling cascades and remodel chromatin structure.
To reveal the underlying molecular mechanisms,
methods outside classical biochemistry are required,
in particular due to the combinatorial complexity of chromatin PTMs and the transient supramolecular interactions crucial for their recognition.
The aim of this project is thus to develop a novel approach,
combining designer chromatin synthesis and dynamic multiplex single-molecule imaging,
to dissect multivalent signaling processes in chromatin - with a focus on the DNA damage response.
Qualifications:
The ideal candidates for this position have a PhD in biochemistry, biophysics or a related field and have a strong interest
in elucidating molecular mechanisms in chromatin regulation. We are particular looking for candidates with a strong background in:
- single-molecule methods in biological systems
- protein purification handling and characterization
- protein and peptide chemistry
- quantitative / systems biology and modeling.
The position will start in May 2017.
To apply for the position, please send a letter of motivation, a CV and the contact information of two referees to: Prof. Beat Fierz - beat.fierz@epfl.ch
